Product Info:

Morpholine is a colorless hygroscopic liquid with a particular smell (smells like ammonia or fishy smell). It is entirely miscible with water, as well as with lots of organic solvents. But the morpholine solubility is restricted in an alkaline aqueous liquid.

Molecular Formula:


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Structure Formula:



Morpholine is an organic chemical compound. This heterocycle features both amines as well as ether functional groups. It is a base because of the amine. Its conjugate acid is called morpholinium.

The morpholine chemical is a colorless hygroscopic liquid with a particular smell (smells like ammonia or fishy smell). It is entirely miscible with water, as well as with lots of organic solvents. But the morpholine solubility is restricted in an alkaline aqueous liquid.

The vapor stress of the aqueous liquid of morpholine is extremely close to that of water alone. And also, this feature is good for solutions of consistent alkalinity. Morpholine pH value in liquid solution exists in the following table.

Concentration of Morpholine (wt. %)pH


Active content99%
Density0.999 g/mL
Melting point-4.9℃
Boiling point128℃
Flammable temperature310℃
Flash point35℃
Danger class8 (corrosive liquid)
Chroma (platinum-cobalt)15 Max.
Boiling range126℃~130℃


Morpholine has a large range of applications. Including utilized as a chemical intermediate, antioxidant, wax and gloss emulsifier, deterioration prevention, solvent for materials, waxes, casein, and dyes, boiler additive, intermediate in the production of rubber accelerators, and intermediate in the manufacturing of optical brighteners for a cleaning agent.

It is also used as polymerization prevention, a driver for sure chain reactions, gelling agent in the prep work of drivers, a dividing agents for different purification treatments, to maintain thermally cellulose products, and a preservative for publication paper.

Morpholine derivatives are utilized as pesticides, fungicides, herbicides, anesthetics, antiseptics, and analgesics. In addition, various morpholine compounds are also utilized as plasticizers, viscosity improvers, antioxidants, deterioration inhibitors, photo-developing agents, and ink eradicators.

In the textile market, morpholine derivatives are used as lubricating substances, emulsifiers, adjuvants, bleaching agents, and softening representatives. On the other hand, its fatty acid salts are used as surface-active agents and emulsifiers.

1. Rubber Chemicals.

Significant use of morpholine is an intermediate in producing delayed-action type rubber accelerators. Accelerators are added to rubber before fabrication to increase the speed of vulcanization. Considering that throughout manufacture, there is a risk of pre-vulcanization. Especially if heat is entailed or the furnace black instead of network black exists. Delayed-action accelerators are very desirable.

Morpholine-based delayed-action accelerators are normally made by reacting with 2-mercaptobenzothiazole.

2. Corrosion Inhibitors.

Morpholine is widely used to reduce amine’s effects in combating carbonic acid corrosion in condensate return lines of vapor boiler systems. The reaction with water-heavy steam from the boiler condenses when the vapor does, consequently paying for security to the lines, which otherwise would certainly undergo deterioration by the carbonic acid present in the vapor condensate.

Morpholine vapors secure silver and various other steel sheets against rust and stain by acid fumes, such as sulfur dioxide and hydrogen sulfide. The chemical is supplied by evaporation from solution in a solid, such as camphor, or by sublimation from morpholinium N N’-oxydiethylenecarbamate.

Morpholine is a component of rust prevention in the water treatment system that protects against the decay of a chlorinated hydrocarbon in a structure, including the chlorinated hydrocarbon and a large amount of water.

The use of morpholine corrosion inhibitors can protect against rust in metal spray cans as well as shutoff. Designers also use morpholine in boiler feed water as well as DM water. You can ask us about morpholine dosing in boiler feed and DM water.

Morpholine is just one of several amines utilized as phosphates to inhibit greaseproof paper’s destructive activity on steel and various other metals. Di-4-morpholinyl polysulfides have been declared deterioration inhibitors to be added to mineral lubricating oils.

Wind turbine oils, especially, are quickly polluted with water, as well as to safeguard the equipment against rusting, 4,4′-alkylidenedimorpholines, and poly (4-morpholinylmethyl) phenols, have been made use of. Storage tanks, pipes, and other tools for managing petroleum extracts must be safeguarded versus corrosion. Also, for this function, 4,4′-butyl-mercapto morpholine, morpholinium mahogany sulfonates, and morpholine combined with ammonium mahogany sulfonates have been suggested.

3. Separating Agents.

The physical, as well as chemical properties of morpholine, make it useful in various filtration treatments. Marked differences in the solubility of the methyl amines in morpholine have caused a convenient extractive technique for dividing these volatile amines.

The enhancement of morpholine to styrene-containing hydrocarbon combinations enables the isolation of significantly pure styrene by azeotropic distillation. It is said that aldehyde or keto derivatives of morpholine, e.g.

4-formylmorpholine works for separating low-viscosity elements from minerals, pets, fish, as well as vegetable oils. It is reported that morpholine is the favored amine to use in an oil-amine mixture for rubbing organic sulfur substances from fuel gas. Morpholine is also utilized in the filtration of acetylene and also specific olefins.

4. Optical Brighteners.

Morpholine is a vital intermediate in the manufacture of optical brighteners. Optical brighteners are utilized by the soap and detergent sector in the compounding of cleaning agents. The diamino stilbene triazine kind brightener with morpholine as a substituent on one of the triazine rings is particularly efficient on cellulosic.

Having higher chlorine bleaching stability than other brighteners, they are particularly appropriate for residence washing detergents.

5. Pharmaceutical Chemicals.

The physiological activity of the morpholine core is confirmed by the variety of pharmaceutical applications that have been discovered for it.

Hydroperiodide is suitable for incorporating into ointments to treat skin disorders, such as athlete’s foot.

A variety of morpholine derivatives have been referred to as analgesics as well as anesthetics. The 4-benzyl morpholines are particularly effective. 4-(4- Bromobenzyl) morpholine, as an example, is reported to be 75% less harmful than procaine. However almost equal to it in the activity.

Numerous morpholine-derived chemicals are useful as respiratory as well as vasomotor stimulants. For example, the N,N’-ethylene bis (N-alkyl-4-morpholine carboxamides) are valuable since the proportion of active dosage to hazardous dosage is low. The dibutyl by-product, for instance, shows 12 times the activity of nikethamide.

Other pharmaceutical fields in which morpholine has found applications include choleretics, antispasmodics, analeptics, and antimalarials. Furthermore, the use of morpholine as a peptizing representative for preparing liquid diffusions of phenothiazines for anthelmintic purposes has been claimed.

Likewise, using morpholine to prepare soluble salts of certain sulfanilamides has been patented, and numerous derivatives are claimed to have therapeutic worth.

6. Bactericides, Fungicides, and Herbicides.

Regarding morpholine fungicides. A variety of morpholine derivatives have actually been shown to have antiseptic activity. For instance, morpholinium salts of particular acylated sulfonamides have solid bacteriostatic or antiseptic homes, and morpholine hydroperiodide has been utilized as a water disinfectant.

The reaction of morpholine with 3,4,5-trichloro-2,6- pyridinedicarbonitrile yields a useful product in controlling fungi.

Morpholine fungicides are used to prepare exceptional herbicides that can be applied to the soil before the weeds emerge or to the growing plants.

7. Antioxidants.

Along with its corrosion prevention, 4-tbutylmercaptomorpholine has been utilized as an antioxidant for lubing oils. In addition, di-4-morpholinyl monosulfide has been declared a lubricating oil stabilizer and multifunctional oil ingredient with antioxidant homes that can be prepared from wax phenols, formaldehyde, and as morpholine.

Small quantities of morpholine and also 1-ascorbic acid is claimed to show significant synergistic antioxidant homes for usage in fatty items. For example, the morpholine salt of gallic acid is an oil-soluble antioxidant for glyceridic oils. Also, a stabilizer for vitamin An, carotene, and 4-alkyl morpholines has been discovered to function as stabilizers for 2-chlorothiophene.

8. Wax Emulsifiers and Surface-Active Agents.

It forms soaps with excellent emulsifying buildings when morpholine responds with fatty acids. Oleic soap is a particularly important emulsifier used in the solution of self-polishing waxes and glosses. The main benefits of morpholine-based emulsifiers are the similar boiling points of morpholine and water.

When the freely bound fatty acid-morpholine compound breaks down, the morpholine part evaporates at roughly the exact same price as the water. As a result, the resultant wax movie is left dry as well as void of morpholine. And also is then extremely water-resistant. This is a really desirable feature in house and vehicle waxes and also polishes.

The response items of morpholine and tung or linseed oil have been discovered to be excellent emulsifying and distributing agents. Likewise, the quaternary alkylammonium sulfates of Mannich bases from morpholine and mono- or polyhydric phenols have been patented as emulsifying and wetting agents.

Several other morpholine-containing compounds have been utilized as wetting chemicals, and it is stated that morpholinium linoleate is a specifically good surface area tension depressor for use in rust-preventive compositions due to the fact that it often hardens the rust-preventive film.

The morpholine salt of a polymeric maleamic acid has been used in compositions for finish paper, cloth, and so on. In addition, small quantities of morpholine have been incorporated in fireproofing materials, and the enhancement of morpholine has boosted the stability of particular asphalt solutions.

This amine has additionally been utilized as a dispersing and also equalizing agents in dye baths and printing pastes, and its quaternary alkyl ammonium sulfates have been patented as general surface-active agents.

9. Miscellaneous Applications.

Morpholine derivatives have found application in the fabric market. Thus, a biquaternary compound that originated from 4,4′-ethylenedimorpholine appropriates as a natural or regenerated cellulose softening chemical. In viscose spinning, small amounts of quaternary morpholine derivatives, presented into either the viscose remedy or regenerating bathroom, avoid fouling the spinnerets throughout extrusion.

Compounds of this type are also helpful as fabric lubricating compounds and sizing emulsifiers. A superior whitening agent for fabrics consists of morpholine in the formula, and α-4- morpholinyl acrylic esters have been claimed as fabric adjuvants.

A compound prepared from sulfur dioxide and morpholine is useful in photographic programmers, as well as a percentage of morpholine in the recipe that improves the maintaining qualities of a fine-grain programmer.

Morpholinium salts of sulfonated azo dye parts use incompletely dry mixes to manufacture dye pictures by electrolytic recording approaches.

Morpholine is utilized in an ink eradicator solution to eliminate graphic arts ink. The eradicator APPLICATIONS allows the customer to promptly change his original graphic representation.

A strongly basic ion-exchange resin can be prepared with a polymerized 4,4′-diallylmorpholinium bromide with alkali. Also, it is reported that a quaternary morpholinium ethosulfate serves as a hair conditioner and deodorant in preferred wave solutions. The ethosulfate is also located in mouthwashes as well as hair shampoos.

A procedure for citric acid by fermentation includes a small quantity of morpholine in the mash. It has been discovered that dimorpholinium oxalate is a superb precipitant for trivalent gold. A fast test for acrylates and acrylonitrile relies on a reaction with morpholine as a first step.

Morpholine might be made use of alone to thermally stabilize cellulose materials. Electric graded kraft documents treated with morpholine will certainly preserve a greater degree of their original tensile strength after subjection to warmth aging.

It is used to prevent damage to paper, specifically in books. The paper is impregnated with aeriform morpholine, thereby elevating the paper’s pH and removing the acidic problems that create its damage.

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It will be broken down on burning. This creates harmful fumes of nitrogen oxides as well as carbon monoxide. The substance is a medium-strong base. Responds with strong oxidants. This generates a fire threat. Corros plastics, rubber, as well as coverings. Unstable if kept in copper or zinc containers.

Morpholine can affect you when breathed in and might be absorbed by the skin.

It is a destructive chemical, and the call can badly irritate the skin and eyes with possible eye damage.

Breathing in it can aggravate the nose, throat, and lungs. Morpholine may damage the liver as well as the kidneys. This chemical has a fire hazard. And also, it is a flammable liquid.

So, you need to know the first aid of this chemical.

  • Eye contact

Right away, flush with large quantities of water for at least half an hour, lifting upper and lower lids. Eliminate call lenses, if worn, while flushing. Look for medical assistance instantly.

  • Skin contact

Quickly take off polluted apparel. Right away, wash polluted skin with huge amounts of soap and water. Look for medical attention.

  • Inhalation

Move the person from direct exposure.

Begin rescue breathing if breathing has stopped. CPR is important if heart action has stopped.

A transfer without delay to a clinical center.


110-91-8, 1-Oxa-4-azacyclohexane, Tetrahydro-1 4-oxazine, Diethylene oximide.


  1. Morpholine compound summary –
  2. CAMEO Chemicals
  3. CAMEO Chemical Reactivity Classification
  4. ILO International Chemical Safety Cards (ICSC)
  5. EPA Chemicals under the TSCA